Author

J. Andersen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Cancer Biology· 2 Cell Biology· 2 Biochemistry· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Organism:human· 4 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:drug response / drug discovery· 2 Organism:C. elegans· 1

Frequent Co-Authors

M. Chamoli· 2 shared N. Braun· 2 shared A. A. Shahmirzadi· 1 shared A. B. F. Barletta· 1 shared A. Foulger· 1 shared A. Gerencser· 1 shared A. Huang· 1 shared A. Sinz· 1 shared

Activity by Year

2019-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 9 mutual co-author links

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2 shared papersCell Biology

M. Chamoli

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Multimodal single-cell profiling reveals cancer crosstalk between macrophages and stromal cells in poor prognostic cholangiocarcinoma patients.

L. R. Heij, S. Hayat, K. Reichel, S. Maryam, C. Rourke, X. Tan, M. van den Braber, J. Verhoeff, M. Halder, F. Peisker, G. Wiltberger, J. Bednarsch, D. Heise, J. Campello Deierl, S. Lang, , U. Neumann

This study uses multimodal single-cell profiling to identify immune cell crosstalk mechanisms in poor prognostic cholangiocarcinoma, revealing key ligand pairs and pathways contributing to immune exhaustion.

bioRxiv · Feb 3, 2024Cancer Biology

Fusion crystallization reveals the behavior of both the 1TEL crystallization chaperone and the TNK1 UBA domain

S. Nawarathnage, Y.-J. Tseng, S. Soleimani, T. Smith, M. J. Pedroza-Romo, W. O. Abiodun, C. Egbert, D. Madhysanka, D. Bunn, B. Wood, E. Tsubaki, C. Stewart, S. Brown, T. Doukov, J. Andersen, J. D. Moody

The paper describes the use of TELSAM fusion crystallization to determine the structure of the TNK1 UBA domain and its interaction with polyubiquitin.

bioRxiv · Jun 14, 2023Biochemistry

Genetic exchange in Leishmania is facilitated by IgM natural antibodies

T. D. Serafim, E. Iniguez, A. B. F. Barletta, J. S. P. Doehl, M. Short, J. Lack, P. Cecilio, V. Nair, M. Disotuar, T. Wilson, I. V. Coutinho-Abreu, F. Oliveira, C. Meneses, C. Barillas-Mury, J. Andersen, , J. G. Valenzuela

This study shows IgM antibodies facilitate Leishmania genetic hybridization in vitro and in vivo, leading to full genome hybrids and increased genetic exchange.

bioRxiv · Jun 9, 2022 · PreprintMicrobiology

VRK1 is a Paralog Synthetic Lethal Target in VRK2-methylated Glioblastoma

J. A. Shields, S. R. Meier, M. Bandi, M. Dam Ferdinez, J. L. Engel, E. E. Mulkearns-Hubert, N. Hajdari, K. Mitchell, W. Zhang, S.-c. Zhao, M. Zhang, R. Tjin Tham Sjin, E. Wilker, J. Lathia, J. Andersen, , N. Emmanuel

This study identifies VRK1 as a synthetic lethal target in VRK2-methylated glioblastoma by showing that VRK1 inhibition leads to tumor growth inhibition in xenograft models.

bioRxiv · Dec 30, 2021 · PreprintCancer Biology

High-throughput characterization of photocrosslinker-bearing ion channel variants to map residues critical for function and pharmacology

N. Braun, S. Friis, C. Ihling, A. Sinz, J. Andersen, S. A. Pless

The paper develops a high-throughput method to study functional and pharmacological properties of ncAA-containing hASIC1a variants using automated patch-clamp.

bioRxiv · Nov 24, 2020Biophysics

The Mitochondrial Permeability Transition Pore Activates the Mitochondrial Unfolded Protein Response and Promotes Aging

S. Angeli, A. Foulger, M. Chamoli, T. H. Peiris, A. Gerencser, A. A. Shahmirzadi, J. Andersen, G. Lithgow

This study shows that loss of OSCP in C. elegans activates the mPTP, triggers UPRmt, and shortens lifespan, while mPTP inhibition restores lifespan.

bioRxiv · Nov 3, 2020Cell Biology

Mechanism and site of action of big dynorphin on ASIC1a

C. B. Borg, N. Braun, S. A. Heusser, Y. Bay, D. Weis, I. Galleano, C. Lund, W. Tian, L. M. Haugaard-Kedstroem, E. P. Bennett, T. Lynagh, K. Stromgaard, J. Andersen, S. Pless

This study identifies the binding site and mechanism of big dynorphin on ASIC1a, revealing the acidic pocket as the interaction site and highlighting its potential for therapeutic development.

Proceedings of the National Academy of Sciences · Mar 12, 2020Peer-reviewedBiophysics

Lifespan-increasing drug nordihydroguaiaretic acid inhibits p300 and activates autophagy

T. Tezil, M. Chamoli, C.-P. Ng, R. P. Simon, V. J. Butler, M. Jung, J. Andersen, A. W. Kao, E. Verdin

This study identifies p300 as a target of NDGA, showing it inhibits p300 acetyltransferase activity and activates autophagy, contributing to lifespan extension.

bioRxiv · Jul 30, 2019Cell Biology