Sphingomyelin suppresses Hedgehog signaling by restricting cholesterol accessibility at the ciliary membrane
M. Kinnebrew, E. J. Iverson, B. Patel, G. V. Pusapati, J. H. Kong, K. A. Johnson, G. Luchetti, D. Covey, C. Siebold, A. Radhakrishnan, R. Rohatgi
This study identifies sphingomyelin's role in restricting cholesterol accessibility at the ciliary membrane, thereby suppressing Hedgehog signaling.
bioRxiv · Jul 16, 2019 · PreprintCell Biology