Author

A. Radhakrishnan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Biochemistry· 1 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Approach:biophysical modeling· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

K. A. Johnson· 2 shared A. Singh· 1 shared B. Patel· 1 shared B. Y. Soong· 1 shared C. D. Corley· 1 shared C. F. Basler· 1 shared C. Liao· 1 shared C. Siebold· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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2 shared papersCell Biology

K. A. Johnson

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5 papers

Recent·Most cited

Single-cell image-based genetic screens systematically identify regulators of Ebola virus subcellular infection dynamics

R. J. Carlson, J. J. Patten, G. Stefanakis, B. Y. Soong, A. Radhakrishnan, A. Singh, N. Thakur, G. K. Amarasinghe, N. Hacohen, C. F. Basler, D. Leung, C. Uhler, R. A. Davey, P. C. Blainey

This study uses single-cell image-based CRISPR screens to identify host factors regulating Ebola virus infection, revealing new therapeutic targets like UQCRB and STRAP.

bioRxiv · Apr 6, 2024 · PreprintMicrobiology

A concerted mechanism involving ACAT and SREBPs by which oxysterols deplete accessible cholesterol to restrict microbial infection

D. B. Heisler, K. A. Johnson, M. B. Ohlson, D. H. Ma, L. Zhang, M. Tran, C. D. Corley, M. E. Abrams, J. G. McDonald, J. W. Schoggins, N. M. Alto, A. Radhakrishnan

This paper identifies a mechanism by which oxysterols like 25HC deplete accessible cholesterol from plasma membranes via ACAT activation and SREBP suppression to restrict microbial infection.

bioRxiv · Oct 10, 2022Cell Biology

Elevation of TRPV1 expression on T cells during experimental immunosuppression

P. S. Kumar, T. Mukherjee, S. Khamaru, A. Radhakrishnan, D. J. N. Kishore, S. Chawla, S. S. Sahoo, S. Chattopadhyay

This study shows TRPV1 expression increases during T cell immunosuppression and contributes to elevated intracellular calcium levels, similar to immune activation.

bioRxiv · Mar 4, 2021Immunology

Molecular Basis for the Adaptive Evolution of Environment Sensing by H-NS Proteins

X. Zhao, V. Kharchenko, U. F. Shahul Hameed, C. Liao, F. Huser, J. M. Remington, A. Radhakrishnan, M. Jaremko, Łukasz Jaremko, S. T. Arold, J. Li

This study investigates how H-NS proteins evolved to sense environmental changes by comparing orthologs from different bacteria and using biophysical methods to reveal electrostatic interactions involved in adaptation.

bioRxiv · Apr 21, 2020Biochemistry

Sphingomyelin suppresses Hedgehog signaling by restricting cholesterol accessibility at the ciliary membrane

M. Kinnebrew, E. J. Iverson, B. Patel, G. V. Pusapati, J. H. Kong, K. A. Johnson, G. Luchetti, D. Covey, C. Siebold, A. Radhakrishnan, R. Rohatgi

This study identifies sphingomyelin's role in restricting cholesterol accessibility at the ciliary membrane, thereby suppressing Hedgehog signaling.

bioRxiv · Jul 16, 2019 · PreprintCell Biology