B. Patel

Diversity and abundance of tree microhabitats in the tropical forests of southern Western Ghats, India

The paper conducts an inventory of tree microhabitats (TMHs) and their host trees in tropical forests of southern Western Ghats, finding significant relationships between TMH abundance and forest structure and species composition.

Differentiation marker-negative CD4+ T cells persist after yellow fever virus vaccination and contribute to durable memory

The paper identifies TMN CD4+ T cells that persist after YFV vaccination and contribute to long-term immunological memory.

STAT3 protects HSCs from intrinsic interferon signaling and loss of long-term blood-forming activity

This study shows that STAT3 is essential for maintaining hematopoietic stem cell function by suppressing interferon signaling and myeloid skewing, and its loss leads to impaired hematopoietic activity.

Differential CpG methylation at Nnat in the early establishment of beta cell heterogeneity

This study identifies differential CpG methylation at the Nnat gene as a mechanism establishing beta cell heterogeneity during development and its potential role in diabetes.

Single-cell multi-omic analysis of the vestibular schwannoma ecosystem uncovers a nerve injury-like state

The paper analyzes single-cell multi-omic data from vestibular schwannomas to identify a nerve injury-like state in tumor-associated Schwann cells linked to myeloid cell recruitment and tumor growth.

Making Biomedical Research Software FAIR: Actionable Step-by-step Guidelines with a User-support Tool

This paper provides actionable step-by-step guidelines and a user-support tool to help biomedical researchers make their software compliant with FAIR4RS principles.

A Spatial Transcriptomics Study of the Brain-Electrode Interface in Rat Motor Cortex

This study uses spatial transcriptomics to analyze gene expression changes in rat motor cortex after electrode implantation, identifying 5811 differentially expressed genes across timepoints.

Single Cell Atlas of Human Dura Reveals Cellular Meningeal Landscape and Insights into Meningioma Immune Response

This study uses single-cell RNA-sequencing to characterize human dura and meningioma, revealing distinct immune microenvironments and TCR overlap between matched samples.

High mannose N-glycans on red blood cells as phagocytic ligands, mediating both sickle cell anaemia and resistance to malaria

High-density, targeted monitoring of tyrosine phosphorylation reveals activated signaling networks in human tumors

This paper introduces SureQuant pTyr, a targeted mass spectrometry method for sensitive and reproducible profiling of tyrosine phosphorylation in human colorectal tumors, revealing dysregulated signaling networks.

Deep analysis of the USP18-dependent ISGylome and proteome unveils important roles for USP18 in tumour cell antigenicity and radiosensitivity

This study identifies novel ISGylation targets regulated by USP18, showing its role in enhancing tumour cell antigenicity and reducing radiosensitivity in CML cells.

Systematic identification of factors bound to isolated metaphase ESC chromosomes reveals a role for chromatin repressors in compaction

The paper identifies proteins bound to metaphase ESC chromosomes and shows chromatin repressors are involved in maintaining chromosome compaction.

A cell-based evaluation of a non-essential amino acid formulation as a non-bioactive control for activation and stimulation of muscle protein synthesis using ex vivo human serum

This study evaluates a non-essential amino acid (NEAA) formulation as a control for comparing bioactivity of proteins on muscle protein synthesis (MPS) using ex vivo human serum.

Sphingomyelin suppresses Hedgehog signaling by restricting cholesterol accessibility at the ciliary membrane

This study identifies sphingomyelin's role in restricting cholesterol accessibility at the ciliary membrane, thereby suppressing Hedgehog signaling.