Author

M. Kinnebrew

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:gene regulatory network inference· 1 Approach:mechanistic / dynamical model· 1 Organism:mouse· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

R. Rohatgi· 3 shared C. Siebold· 2 shared G. V. Pusapati· 2 shared A. M. Lebensohn· 1 shared A. Radhakrishnan· 1 shared B. Ansell· 1 shared B. B. Patel· 1 shared B. Patel· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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3 shared papersCell Biology

R. Rohatgi

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Direct ionic stress sensing and mitigation by the transcription factor NFAT5

C. B. Khandwala, P. Sarkar, H. B. Schmidt, M. Ma, M. Kinnebrew, G. V. Pusapati, B. B. Patel, D. Tillo, A. M. Lebensohn, R. Rohatgi

This study identifies NFAT5 as a direct sensor and effector of ionic stress in animal cells, showing it forms condensates to activate genes restoring ion balance.

bioRxiv · Sep 23, 2023Cell Biology

The Energetics and Ion Coupling of Cholesterol Transport Through Patched1

B. Ansell, R. A. Corey, L. V. Viti, M. Kinnebrew, R. Rohatgi, C. Siebold, M. Sansom

The paper uses molecular dynamics simulations and biochemical assays to study cholesterol transport through PTCH1, finding energetic barriers and ion-coupling mechanisms for cholesterol export.

bioRxiv · Feb 14, 2023Biophysics

Sphingomyelin suppresses Hedgehog signaling by restricting cholesterol accessibility at the ciliary membrane

M. Kinnebrew, E. J. Iverson, B. Patel, G. V. Pusapati, J. H. Kong, K. A. Johnson, G. Luchetti, D. Covey, C. Siebold, A. Radhakrishnan, R. Rohatgi

This study identifies sphingomyelin's role in restricting cholesterol accessibility at the ciliary membrane, thereby suppressing Hedgehog signaling.

bioRxiv · Jul 16, 2019 · PreprintCell Biology