BiochemistrybioRxivPreprint
PHARMACOLOGICAL PROTEIN INACTIVATION BY TARGETING FOLDING INTERMEDIATES
G. Spagnolli, T. Massignan, A. Astolfi…·E. Biasini
The paper discovers non-native metastable states in protein folding pathways and develops a novel drug discovery approach, PPI-FIT, to target these intermediates to lower protein expression.
DOI 10.1101/2020.03.31.018069