Hyaluronidase-1-mediated glycocalyx impairment underlies endothelial abnormalities in polypoidal choroidal vasculopathy
K.-X. Wu, N. J. Y. Yeo, C.-Y. Ng, F. W. J. Chioh, Q. Fan, X. Tian, B. Yang, G. Narayanan, H. M. Tay, H. W. Hou, R. N. Dunn, X. Su, C. M. G. Cheung, C. Cheung
This study identifies hyaluronidase-1 as a key driver of glycocalyx impairment in PCV BOECs, linking it to endothelial dysfunction and proposing it as a therapeutic target.
bioRxiv · Oct 6, 2021Cell Biology