B. Yang

Evaluate the efficiency of Mr BMT in macrophage replacement of peripheral organs

This study evaluates Mr BMT's efficiency in replacing macrophages in peripheral organs, finding comparable replacement efficiencies to traditional BMT in liver, kidney, lung, and spleen.

Engineering the Mechanical Stability of a Therapeutic Affibody/PD-L1 Complex by Anchor Point Selection

The paper investigates how anchor point selection affects the mechanical stability of an Affibody/PD-L1 complex using multiple experimental and computational methods.

Recombinant expression, purification, and antifungal activity of the novel antimicrobial peptide TaW662

This study identifies and characterizes TaW662, an antifungal peptide from wheat, showing inhibition of Blumeria graminis f. sp. tritici growth and potential as a fungicide.

A rat model of cirrhosis with well-differentiated hepatocellular carcinoma induced by thioacetamide

This study develops a rat model of cirrhosis-induced hepatocellular carcinoma using thioacetamide, showing fibrosis, altered liver architecture, and increased AFP levels.

Patch-walking: Coordinated multi-pipette patch clamp for efficiently finding synaptic connections

The paper introduces a method called patch-walking to improve the efficiency of finding synaptic connections by reusing a single patch clamp electrode, resulting in more connections probed per experiment.

A hemagglutinin and neuraminidase biased immunological memory shapes the dynamics of antibody responses to Influenza A virus

The paper shows that pre-existing immunity to specific influenza antigens biases post-infection antibody responses, altering their dynamics and breadth.

Integrating Dynamic Network Analysis with AI for Enhanced Epitope Prediction in PD-L1:Affibody Interactions

The paper develops an integrated method combining dynamic network analysis with AI to predict epitopes in PD-L1:Affibody interactions, showing the perpendicular binding mode is more stable.

The kinematics and aerodynamics of hinged wing of honeybees during takeoff

This study analyzes honeybee wing kinematics during takeoff, revealing key parameters and the role of hinged wings in thrust generation.

Identification of a Novel Ferroptosis Inducer with Dual Modulatory Effects on GPX4 Activity and Stability

This study identifies MI-2, a novel GPX4 inhibitor that induces ferroptosis by inhibiting GPX4 activity and promoting its degradation, showing synergistic effects with existing cancer drugs.

Loss-of-function mutation in the polyamine transporter gene OsLAT5 as a selectable marker for genome editing

The paper demonstrates that loss-of-function mutations in OsLAT5 confer resistance to methylviologen, providing a selectable marker for genome editing in rice.

The chemotherapy-induced senescence-associated secretome promotes cell detachment and metastatic dissemination through metabolic reprogramming

This study shows that chemotherapy-induced senescence-associated secretome promotes metastasis in ovarian cancer by reprogramming metabolism and increasing cell detachment.

ATR promotes mTORC1 activity via de novo cholesterol synthesis

This study shows ATR enhances mTORC1 activity through cholesterol synthesis via LSS, independent of CHK1 and TSC, and this effect is amplified in p16-deficient cells.

Gut microbial genomes with paired isolates from China signify probiotic and cardiometabolic effects

The paper presents a new microbial reference set with paired isolates from China, showing probiotic and cardiometabolic effects on hosts.

Olfactory learning in Drosophila requires O-GlcNAcylation of mushroom body ribosomal subunits

This study identifies O-GlcNAcylation of mushroom body ribosomal subunits as essential for olfactory learning in Drosophila, showing that reducing O-GlcNAcylation impairs learning.

Engineering an artificial catch bond using mechanical anisotropy

The paper demonstrates how modifying anchor geometry can generate catch bonding behavior in the DocG:CohE adhesion complex, showing mechanical anisotropy enables engineered catch bonds.

Tree diversity increases forest temperature buffering

This study shows that higher tree species diversity enhances forest temperature buffering across multiple time scales, mediated by canopy density and structural diversity.

Lipid-anchored Proteasomes Control Membrane Protein Homeostasis

This study identifies N-myristoylation of Rpt2 as a mechanism for proteasome-membrane interaction, showing its role in membrane protein homeostasis and its impact on cellular processes and tumor growth.

Direct measurements of collagen fiber recruitment in the posterior pole of the eye

This paper directly measures collagen fiber recruitment in the peripapillary sclera and lamina cribrosa under stretch, finding sigmoidal recruitment curves with PPS recruiting faster and at lower stretch than LC.

ZBP1-mediated macrophage necroptosis inhibits ASFV replication

This study identifies ZBP1-mediated macrophage necroptosis as a mechanism that inhibits ASFV replication by promoting proinflammatory cytokine release.

Efficient protein tagging and cis-regulatory element engineering via precise and directional oligonucleotide-based targeted insertion in plants

This study improves targeted insertion in plants using chemically protected dsODNs with 5' 1-nt overhangs, achieving directional and precise insertions for gene tagging and cis-regulatory engineering in Setaria viridis and rice.

A correlative study of the genomic underpinning of virulence traits and drug tolerance of Candida auris

This study compares two Candida auris isolates to identify genetic and metabolic differences linked to drug resistance and immune evasion.

Uncovering and engineering the mechanical properties of the adhesion GPCR ADGRG1 GAIN domain

This study investigates the mechanical properties of the ADGRG1 GAIN domain using single-molecule force spectroscopy and simulations, revealing structural mechanisms that enhance mechanical resistance and informing potential drug design.

Alteration of pro-carcinogenic gut microbiota is associated with clear cell renal cell carcinoma tumorigenesis

This study identifies associations between gut microbiota composition and serum metabolites with clear cell renal cell carcinoma, suggesting potential risk factors for tumorigenesis.

Human USP18 protects diverse cancer lineages from Type I Interferon independently of its canonical catalytic function

This paper shows USP18's scaffold function, not its catalytic activity, is critical for inhibiting cancer growth and Type I interferon signaling in human cells.

Cross-species single-cell comparison of systemic and cardiac inflammatory responses after cardiac injury

This study compares systemic and cardiac inflammatory responses to injury in mice and zebrafish using single-cell transcriptomics, revealing distinct monocyte/macrophage transcriptional clusters and divergent responses between species.

PRL1 negatively regulates Rho GTPase-independent and -dependent signaling pathways maintaining actin microfilament dynamic for pavement cell morphogenesis

This study identifies PRL1 as a regulator of actin microfilament dynamics in Arabidopsis pavement cells through both Rho GTPase-dependent and -independent pathways.

HIV-differentiated metabolite N-Acetyl-L-Alanine dysregulates human natural killer cell responses to Mycobacterium tuberculosis infection

The paper identifies N-Acetyl-L-Alanine as a metabolite dysregulated by HIV that inhibits NK cell responses to Mycobacterium tuberculosis infection.

NuSAP participates in metaphase spindle length control in mammalians

This study identifies NuSAP's role in regulating metaphase spindle length by controlling microtubule flux and Kif2A localization during mitosis.

Dying cell-released exosomal CXCL1 promotes breast cancer metastasis by activating TAM/PD-L1 signaling

This study shows that exosomal CXCL1 from dying breast cancer cells promotes metastasis by activating TAM/PD-L1 signaling and identifies TPCA-1 as a potential inhibitor.

Plasmacytoid dendritic cells mediate CpG-ODN induced increase in survival in a mouse model of lymphangioleiomyomatosis

This study shows that CpG-ODN improves survival in a mouse LAM model by enhancing immune responses, mediated by plasmacytoid dendritic cells, and synergizes with anti-PD1 and rapamycin.