X. Su

SLC45A4 encodes a peroxisomal putrescine transporter that promotes GABA de novo synthesis

The paper identifies SLC45A4 as a peroxisomal putrescine transporter that enhances GABA de novo synthesis via the AOP pathway.

The cGAS-STING Pathway Is Essential in Acute Ischemia-Induced Neutropoiesis and Neutrophil Priming in the Bone Marrow

This study shows that the cGAS-STING pathway is essential for neutrophil production and function in the bone marrow during acute myocardial ischemia, promoting myocardial repair.

Coral larvae employ nitrogen sequestration mechanisms to stabilize carbon provisioning from algal symbionts under increased temperature

This study shows coral larvae maintain carbon provisioning from algal symbionts under heat stress by sequestering nitrogen into dipeptides, reducing symbiont growth but preserving photosynthesis and carbon transfer.

Transcriptome-wide mapping of small-molecule RNA-binding sites in live cells

This paper describes a method to map small-molecule RNA-binding sites in live cells and identifies their targets and binding sites.

RESPIRATION DEFECTS LIMIT SERINE SYNTHESIS REQUIRED FOR LUNG CANCER GROWTH AND SURVIVAL

This study shows that mitochondrial DNA mutations in NSCLC cause respiration defects, leading to glucose dependency, reduced serine synthesis, and increased cancer survival.

The Transcription Factor OsNAC5 Mediates Cadmium Stress Response and Accumulation in Rice

This study identifies OsNAC5 as a transcription factor that regulates Cd uptake in rice by activating OsNRAMP1, reducing Cd accumulation in grains.

Deep learning based genomic breeding of pest-resistant grapevine

This study uses deep learning and genome-wide association studies to identify pest-resistant genes in grapevine, achieving high accuracy in predicting pest damage.

A rapid and efficient in vivo inoculation method for introducing tree stem canker pathogens onto leaves: Suitable for large-scale assessment of resistance in poplar breeding progeny

This paper introduces an in vivo leaf inoculation method for assessing poplar resistance to V. sordida, showing it is more efficient and suitable for large-scale screening than traditional stem segment inoculation.

Antimicrobial resistance, virulence genes profiles and molecular epidemiology of carbapenem-resistant Klebsiella pneumoniae strains from captive giant pandas (Ailuropoda melanoleuca)

This study analyzed antibiotic resistance, virulence genes, and molecular epidemiology of CRKP strains from giant pandas, revealing diverse genetic profiles and high genetic diversity.

Growth phase-dependent reorganization of cryptophyte photosystem I antennae

This study identifies growth phase-dependent rearrangements of photosystem I antennae in cryptophytes and characterizes a unique protein involved in light-harvesting.

Chlamydial protease-like activating factor targets SLC7A11 for degradation to induce ferroptosis and facilitate dissemination.

This study identifies CPAF-mediated degradation of SLC7A11 as a mechanism for Chlamydia-induced ferroptosis, promoting bacterial dissemination and suggesting therapeutic targeting.

DNA-protein interaction is dominated by short anchoring elements

The paper identifies short anchoring elements (AEs) that dominate DNA-protein interactions for four TFs and develops AEEscape to analyze their binding energy landscapes.

Exhaustive search for DNA binding sites of Basillus subtilis transcription factor YsiA by KaScape method

This study uses KaScape to identify YsiA DNA binding sites in B. subtilis, finding that half-sites suffice for binding and revealing new minor sequences.

G6PD Maintains Redox Homeostasis and Biosynthesis in LKB1-Deficient KRAS-Driven Lung Cancer

This study shows that G6PD is critical for redox balance and biosynthesis in LKB1-deficient KRAS-driven lung cancer, but not in KP tumors, and identifies potential therapeutic strategies.

IDR-induced CAR condensation improves the cytotoxicity of CAR-Ts against low-antigen cancers

This study shows that adding intrinsically disordered regions (IDRs) to CARs improves their cytotoxicity against low-antigen cancers by enhancing signaling and killing activity.

BRG1/BRM inhibitor targets AML stem cells and exerts superior preclinical efficacy combined with BET or Menin inhibitor

This study shows that FHD-286, a BRG1/BRM inhibitor, reduces AML burden and improves survival when combined with Menin or BET inhibitors in xenograft models of AML with MLL1r or mtNPM1.

Dynamics of endogenous and water cortisol release in Asian Seabass Lates calcarifer after acute stress in a farm scale recirculating aquaculture system

This study measures cortisol dynamics in Asian Seabass under acute stress in a farm-scale RAS, showing varying temporal patterns in plasma, mucus, fin, and water cortisol.

KaScape: A sequencing-based method for global characterization of protein-DNA binding affinity

KaScape quantitatively characterizes TF-DNA binding affinity across all possible sequences using next-generation sequencing and provides a tool to visualize the affinity landscape.

Use of Artificial Intelligence for Automated Detection and Surveillance of Red Imported Fire Ants Nests

This study develops an AI system using robotic dogs to detect red imported fire ant nests with 95% precision, improving surveillance and pesticide delivery in open fields.

Spatially-resolved single-cell atlas of ascidian endostyle provides insights into the origin of vertebrate pharyngeal organs

The paper constructs a spatially-resolved single-cell atlas of the ascidian endostyle, identifying new cell types and evolutionary insights into vertebrate pharyngeal organs.

Therapeutic targeting of ACLY in T-ALL in vivo

This study identifies ACLY as an overexpressed therapeutic target in T-ALL, showing its antileukemic effects and reciprocal relationship with MYC.

Tumour Extracellular Vesicles Induce Neutrophil Extracellular Traps To Promote Lymph Node Metastasis

This study shows that tumor-derived extracellular vesicles induce neutrophil extracellular traps in lymph nodes, promoting metastasis and identifying potential therapeutic targets.

A novel order-level lineage of ammonia-oxidizing Thaumarchaeota is widespread in marine and terrestrial environments

The paper identifies a new AOA order, Nitrosomirales, widespread in marine and terrestrial environments, showing metabolic versatility and horizontal gene transfer.

Linking genotypic and phenotypic changes in the E. coli Long-Term Evolution Experimentusing metabolomics

The paper links mutations to metabolic changes and fitness in E. coli from the LTEE using metabolomics and integrates this with mutation and expression data.

Insights into the Microbial Weathering of Chinese Wooden Ancestral Halls in Guangdong Province

The paper analyzes microbial diversity in ancestral halls in Guangdong Province, identifying cellulose- and lignin-degrading microbes and evaluating biocides for wood preservation.

At-home saliva sampling in healthy adults using CandyCollect, a lollipop-inspired device

The paper demonstrates that the CandyCollect device effectively collects salivary bacteria with 100% concordance with traditional methods and is preferred by users.

DeepAIR: a deep-learning framework for effective integration of sequence and 3D structure to enable adaptive immune receptor analysis

DeepAIR integrates sequence and 3D structure features of adaptive immune receptors to predict binding affinity and reactivity, outperforming existing methods on multiple tasks.

An Open Microfluidic Coculture Model of Fibroblasts and Eosinophils to Investigate Mechanisms of Airway Inflammation

This paper introduces an open microfluidic coculture model of fibroblasts and eosinophils to study bidirectional signaling in airway inflammation, showing proinflammatory fibroblast activation and potential eosinophil feedback.

Tumor subclones, where are you?

This study compares bulk and single-cell mutational analysis to assess tumor clonal structure, finding that bulk analysis underestimates subclonal complexity and dynamic evolution.

Identification of a multipotent lung progenitor for lung regeneration

The paper identifies a multipotent lung progenitor that co-expresses endothelial and epithelial markers and contributes to multi-lineage regenerative patches in a transplantation model.