Limb Specific Failure of Proliferation and Translation in the Mesenchyme Leads to Skeletal Defects in Diamond Blackfan Anemia
J. Hom, T. Karnavas, E. Hartman, J. Papoin, Y. Tang, B. M. Dulmovits, M. Khan, H. Patel, J. Bondy, M. Edelman, R. Touraine, G. Chanoz-Poulard, G. Ottenberg, R. Maynard, D. J. Adams, , L. Blanc
This study identifies site-specific skeletal defects in DBA by showing limb-specific mesenchymal stem cell proliferation and translation failures linked to WNT signaling and p53.
bioRxiv · Jan 14, 2022 · PreprintCell Biology