L. Blanc

In tissue spatial single-cell metabolomics by coupling mass spectrometry imaging and immunofluorescences

This paper introduces a multimodal imaging workflow combining MALDI-MSI and IF microscopy to enhance spatial single-cell metabolomics, validated on mouse spleen sections.

BMI1 regulates human erythroid self-renewal through both gene repression and gene activation

This study shows BMI1 promotes erythroid self-renewal through both gene repression and activation, offering a strategy to expand immature erythroid precursors for clinical use.

CDK6-mediated endothelial cell cycle acceleration drives arteriovenous malformations in hereditary hemorrhagic telangiectasia

This study identifies CDK6-driven cell cycle acceleration in endothelial cells as a driver of arteriovenous malformations in HHT, suggesting CDK4/6 inhibitors as potential therapeutic options.

Loss of IRF5 increases ribosome biogenesis leading to alterations in mammary gland architecture and metastasis

This study shows that loss of IRF5 predicts metastasis and survival in breast cancer and reveals its role in regulating ribosome biogenesis and tumor progression.

Arginine-dependent hypusination of the eukaryotic translation initiation factor (eIF)5A drives erythroid lineage differentiation

The paper shows that arginine metabolism via hypusination of eIF5A regulates erythroid differentiation and that impaired eIF5A activity leads to erythroid disorders.

Limb Specific Failure of Proliferation and Translation in the Mesenchyme Leads to Skeletal Defects in Diamond Blackfan Anemia

This study identifies site-specific skeletal defects in DBA by showing limb-specific mesenchymal stem cell proliferation and translation failures linked to WNT signaling and p53.

Modelling Eurasian lynx populations in Western Europe: What prospects for the next 50 years?

The paper models Eurasian lynx populations in Western Europe to predict their persistence over 50 years, finding likely large-scale survival despite challenges.

Sirolimus plus nintedanib treats vascular pathology in HHT mouse models

This study shows that combining sirolimus and nintedanib treats vascular abnormalities in HHT mouse models by targeting multiple pathways.

Phase variation in Mycobacterium tuberculosis glpK produces transiently heritable drug tolerance

This paper identifies a novel mechanism of drug tolerance in M. tuberculosis through phase variation in the glpK gene, showing reversible frameshift mutations that contribute to treatment failure and relapse.

Myosin IIA interacts with the spectrin-actin membrane skeleton to control red blood cell membrane curvature and deformability

This paper shows that myosin IIA interacts with the spectrin-actin membrane skeleton in red blood cells to control membrane curvature and deformability by exerting contractile forces.

Tacrolimus Rescues Endothelial ALK1 Loss-Of-Function Signaling And Improves HHT Vascular Pathology

This study identifies tacrolimus as a drug that activates Smad1/5/8 signaling and reduces vascular pathology in HHT models.

A mouse model of hereditary hemorrhagic telangiectasia generated by transmammary-delivered immunoblocking of BMP9 and BMP10

This study uses transmammary delivery of anti-BMP9/10 antibodies to induce HHT-like vascular defects in mouse neonates, revealing consistent retinal pathology and increased angiopoietin-2 expression.