Cell BiologybioRxivPreprint
Real Time In vivo Analysis of Pancreatic Beta-cell Autophagic Flux Reveals Impairment Before Onset of Autoimmune Diabetes
O. Melnyk, C. Muralidharan, B. Duffett…·A. K. Linnemann
This study uses intravital microscopy to show autophagic flux defects in NOD mouse beta-cells before hyperglycemia onset, suggesting a causal role in T1D pathogenesis.