Cell BiologybioRxiv
Activated BAX/BAK enable mitochondrial inner membrane permeabilisation and mtDNA release during cell death
J. Riley, G. Quarato, J. Lopez…·S. Tait
This study shows that BAX/BAK-mediated mitochondrial outer membrane pores widen after MOMP, leading to inner membrane permeabilisation and mtDNA release, which triggers inflammation via cGAS-STING.
DOI 10.15252/embj.201899238