S. Tait

Mitochondrial outer membrane integrity regulates a ubiquitin-dependent NF-κB inflammatory response

This study shows that mitochondrial outer membrane permeabilization triggers ubiquitin-dependent NF-κB inflammation by recruiting NEMO to ubiquitylated mitochondria.

Intracellular BAPTA directly inhibits PFKFB3, thereby impeding mTORC1-driven Mcl-1 translation and killing Mcl-1-addicted cancer cells

This paper shows that BAPTAi inhibits PFKFB3, reducing mTORC1-driven Mcl-1 translation and killing Mcl-1-dependent cancer cells, independent of Ca2+ signaling.

Increased apoptotic priming of glioblastoma enables therapeutic targeting by BH3-mimetics

This study shows that glioblastoma (GBM) is highly sensitive to BH3-mimetics due to elevated anti-apoptotic BCL-xL and MCL-1 expression, which can be therapeutically targeted.

BRD4-mediated repression of p53 is a target for combination therapy in AML

This study shows that combining MDM2 inhibitors and BET inhibitors synergistically kills AML cells by enhancing p53 activation through BRD4's repressive function.

Distributed Biomanufacturing of Liquefied Petroleum Gas

This paper demonstrates the production of bio-LPG from waste volatile fatty acids using engineered microbes, offering a sustainable alternative to fossil fuels.

Activated BAX/BAK enable mitochondrial inner membrane permeabilisation and mtDNA release during cell death

This study shows that BAX/BAK-mediated mitochondrial outer membrane pores widen after MOMP, leading to inner membrane permeabilisation and mtDNA release, which triggers inflammation via cGAS-STING.