J. Riley

Caspase-2 kills cells with extra centrosomes

The paper shows that caspase-2 triggers apoptosis in cells with extra centrosomes, preventing polyploidization through mitochondrial pathways.

Aberrant Wnt activation in recurrent genetically variant human pluripotent stem cells impairs cardiomyocyte differentiation and phenotype

This study shows that genetic variants in human pluripotent stem cells, specifically gains of chromosome 1q, impair cardiomyocyte differentiation and phenotype through aberrant Wnt activation.

Mitochondrial outer membrane integrity regulates a ubiquitin-dependent NF-κB inflammatory response

This study shows that mitochondrial outer membrane permeabilization triggers ubiquitin-dependent NF-κB inflammation by recruiting NEMO to ubiquitylated mitochondria.

Tyrosine phosphorylation of ACLY regulates lipid metabolism and oncogenesis in ALK positive Anaplastic Large Cell Lymphoma

This study identifies tyrosine phosphorylation of ACLY at Y682 as a regulatory mechanism linked to lipid metabolism and oncogenesis in ALK-positive ALCL.

Activated BAX/BAK enable mitochondrial inner membrane permeabilisation and mtDNA release during cell death

This study shows that BAX/BAK-mediated mitochondrial outer membrane pores widen after MOMP, leading to inner membrane permeabilisation and mtDNA release, which triggers inflammation via cGAS-STING.

Contribution of the β-glucosidase BglC to the Onset of the Pathogenic Lifestyle of Streptomyces scabies

This study investigates the role of β-glucosidase BglC in the pathogenic lifestyle of Streptomyces scabies and finds that its inactivation leads to unexpected thaxtomin production patterns.