Order of amino acid recruitment into the genetic code resolved by Last Universal Common Ancestor's protein domains
S. Wehbi, A. Wheeler, B. Morel, N. Manepalli, B. Q. Minh, D. Lauretta, J. Masel
The paper infers the order of amino acid recruitment into the genetic code by analyzing ancestral protein domain frequencies, finding smaller amino acids were added earlier and metal-binding/sulfur-containing amino acids earlier than previously thought.
bioRxiv · Apr 13, 2024 · PreprintEvolutionary Biology