Cancer BiologybioRxiv
Reconstructing the lineage histories and differentiation trajectories of individual cancer cells in JAK2-mutant myeloproliferative neoplasms
D. Van Egeren, J. Escabi, M. Nguyen…·S. Hormoz
This study reconstructs the lineage histories and differentiation trajectories of JAK2-mutant HSCs in MPN patients, finding the mutation occurs decades before diagnosis and drives exponential growth of mutated HSC populations.
DOI 10.1016/j.stem.2021.02.001