BiochemistrybioRxiv
Stepwise activation mechanism of the scramblase nhTMEM16 revealed by cryo-EM
V. Kalienkova, V. Clerico Mosina, L. Bryner…·C. Paulino
This study uses cryo-EM to reveal the stepwise activation mechanism of nhTMEM16, showing how Ca2+-binding induces conformational changes that facilitate lipid scrambling.
DOI 10.7554/elife.44364