BiochemistrybioRxiv
Rational design of structure-based vaccines targeting misfolded alpha-synuclein conformers of Parkinson's disease and related disorders
J. M. Flores-Fernandez, V. Pesch, A. Sriraman…·H. Wille
This paper designs vaccines targeting misfolded alpha-synuclein by mimicking its fibril structure, inducing antibodies that recognize pathological forms without reacting to native protein.
DOI 10.1002/btm2.10665