Cellular toxicity of iHAP1 and DT-061 does not occur through PP2A-B56 targeting
G. Vit, J. Duro, G. Rajendraprasad, E. P. Hertz, L. Holland, M. B. Weisser, B. McEwan, B. Lopez-Mendez, G. Montoya, N. Mailand, K. Maeda, A. Kettenbach, J. Nilsson
This study challenges previous claims that iHAP1 and DT-061 target PP2A-B56 complexes, showing instead that they exert toxicity through microtubule disruption and ER/Golgi disruption, respectively.
bioRxiv · Jul 8, 2021Cell Biology