Cell BiologybioRxiv
Cigarette smoke exposed airway epithelial cell-derived EVs promote pro-inflammatory macrophage activation in alpha-1 antitrypsin deficiency
N. Khodayari, R. Oshins, B. Mehrad…·M. Brantly
This study shows that cigarette smoke-exposed airway epithelial cell-derived EVs enhance pro-inflammatory activation of AATD macrophages, increasing cytokine production and neutrophil chemoattractant release.
DOI 10.1186/s12931-022-02161-z