Cancer BiologybioRxivPreprint
Gap scheduling of a PARP inhibitor and nanoparticle TOP1 agent combination avoids synergistic bone marrow toxicity
Lenka Oplustil O’Connor, Anderson T. Wang, Claire Sadler…·Mark J. O’Connor
The paper identifies a gap schedule for combining a PARP inhibitor and a tumor-targeted nanoparticle chemotherapy to enhance efficacy while reducing bone marrow toxicity.
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