BiochemistrybioRxivPreprint
FAF1 and FAF2 enhance human p97-UFD1-NPL4 complex unfoldase activity enabling rational design of p97 activators
Pritha Dasgupta, Ian R. Kelsall, Gaurav Anand…·Yogesh Kulathu
This study identifies FAF2 as a strong activator of the p97-UN complex and uses its mechanism to design de novo proteins that enhance p97 activity.
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