NeurosciencebioRxivPreprint
Generation, quality control, and analysis of the first genomically humanised knock-in mice for the ALS/FTD genes SOD1, TARDBP (TDP-43), and FUS
Anny Devoy, Georgia Price, Francesca De Giorgio…·Thomas J. Cunningham
The paper creates genomically humanised knock-in mice for ALS/FTD genes SOD1, TARDBP, and FUS, showing they express human proteins at endogenous levels and are phenotypically normal.
DOI 10.1101/2021.07.05.451113