NeurosciencebioRxivPreprint
Inhibition of LRRK2 kinase activity rescues deficits in striatal dopamine dynamics in VPS35 p.D620N knock-in mice
Mengfei Bu, Jordan Follett, Igor Tatarnikov…·Matthew James Farrer
The paper shows that inhibiting LRRK2 kinase activity rescues dopamine deficits in VPS35 p.D620N knock-in mice by normalizing DAT function and reducing hyperlocomotion.
DOI 10.1101/2023.05.14.540654