Cancer BiologybioRxivPreprint
Targeting IDH1-Mutated Oligodendroglioma with Acid Ceramidase Inhibitors
Helena Muley, Tyrone Dowdy, Faris Zaibaq…·Mioara Larion
This study shows that inhibiting acid ceramidase (AC) induces apoptosis and improves survival in IDH1-mutated oligodendroglioma by increasing ceramide levels and activating both extrinsic and intrinsic apoptosis pathways.
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