In vivo genome-wide CRISPRi-Seq in Streptococcus pneumoniae reveals host-adaptive pathways essential for meningitis and identifies new therapeutic targets
Kin Ki Jim, Andrew Quinn, Vincent de Bakker…·Jan‐Willem Veening
This study uses in vivo CRISPRi-Seq in zebrafish to identify host-adaptive pathways essential for pneumococcal meningitis and discover new therapeutic targets.