GenomicsbioRxivPreprint
RNA G-quadruplexes mark repressive upstream open reading frames in human mRNAs
Pierre Murat, Giovanni Marsico, Barbara Herdy…·Shankar Balasubramanian
The paper identifies RNA G-quadruplexes in 5-UTRs as repressive elements that hinder translation by promoting upstream open reading frames, and shows helicases interact with these structures to regulate translation.