BiochemistrybioRxivPreprint
Higher-order epistatic networks underlie the evolutionary fitness landscape of a xenobiotic- degrading enzyme
Gloria Yang, Dave W Anderson, Florian Baier…·Nobuhiko Tokuriki
This study identifies five mutations that enable the evolution of a xenobiotic-degrading enzyme and shows that higher-order epistasis shapes its adaptive landscape and substrate specificity.
DOI 10.1101/504811