Cancer BiologyCancer CellPeer-reviewed
Mammalian SWI/SNF complex activity regulates POU2F3 and constitutes a targetable dependency in small cell lung cancer
Leslie Duplaquet, Kevin So, Alexander Wang Ying…·Matthew G. Oser
This study identifies mSWI/SNF complex activity as a targetable dependency in POU2F3-positive small cell lung cancer, showing that inhibiting mSWI/SNF or BRD9 reduces tumor growth and improves survival.
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