PathologybioRxivPreprint
O-GlcNAcylation-Ubiquitin Crosstalk of METTL1 Drives m7G Epitranscriptomic Collapse and Lipid Metabolic Reprogramming in Diabetic Cardiomyopathy
Xin Gu, Haoyu Meng, Jiabao Liu…·Yingqiang Du
This study identifies METTL1 O-GlcNAcylation and ubiquitination as key regulators of m7G modification and lipid metabolism in diabetic cardiomyopathy, with a drug targeting this pathway showing therapeutic potential.