Author

Guido Scarabelli

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Biophysics· 1

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Approach:deep learning· 1 Research Focus:protein design· 1 Assay:protein sequence· 1 Approach:statistical model· 1 Research Focus:variant effect prediction· 1

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Eliud O. OlooiD· 1 shared Emily R. Rhodes· 1 shared Jacob Byerly· 1 shared Jonathan JouiD· 1 shared Kayla G. SprengeriD· 1 shared

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2025-2025 · peak 1/yr

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1 shared paperBiophysics

Eliud O. OlooORCID

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1 paper

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BiophysicsbioRxivPreprintOct 28, 2025

Prioritizing Stability-enhancing Mutations using a Protein Language Model in conjunction with Physics-Based Predictions

Emily R. Rhodes, Guido Scarabelli, Jonathan Jou…·Eliud O. Oloo

The paper combines a protein language model and physics-based method to prioritize stability-enhancing mutations, achieving higher accuracy than either method alone.

DOI 10.1101/2025.10.28.683791

protein sequencedeep learning

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