MicrobiologybioRxiv
Antagonism of the azoles to olorofim and cross-resistance are governed by linked transcriptional networks in Aspergillus fumigatus
N. van Rhijn, S. Hemmings, I. S. R. Storer…·M. J. Bromley
This study identifies antagonism between triazoles and olorofim in Aspergillus fumigatus due to transcriptional regulation of pyrimidine and ergosterol pathways, revealing cross-resistance mechanisms.
DOI 10.1128/mbio.02215-22