J. Amich

The sulfur-related metabolic status of Aspergillus fumigatus during infection reveals cytosolic serine hydroxymethyltransferase as a promising antifungal target.

The paper identifies genes involved in sulfur metabolism in Aspergillus fumigatus during infection, highlighting ShmB as a promising antifungal target due to its essential role in virulence and structural differences from the human enzyme.

Aspergillus fumigatus can display persistence to the fungicidal drug voriconazole

This study shows that some Aspergillus fumigatus isolates can persist in the presence of voriconazole, a fungicidal drug, and this persistence is associated with a distinct transcriptional profile and reduced treatment efficacy.

Every single conidium in Aspergillus fumigatus caspofungin tolerant strains are intrinsically caspofungin tolerant

The paper investigates whether caspofungin tolerance in Aspergillus fumigatus is a population-level or individual-level trait by testing conidia from clinical isolates.

Antagonism of the azoles to olorofim and cross-resistance are governed by linked transcriptional networks in Aspergillus fumigatus

This study identifies antagonism between triazoles and olorofim in Aspergillus fumigatus due to transcriptional regulation of pyrimidine and ergosterol pathways, revealing cross-resistance mechanisms.

Targeting methionine synthase in a fungal pathogen causes a metabolic imbalance that impacts cell energetics, growth and virulence

This paper identifies methionine synthase as a promising antifungal target by showing its essentiality in Aspergillus fumigatus and validates its druggability using a genetic model of established infections.

3D light sheet fluorescence microscopy of lungs to dissect local host immune - Aspergillus fumigatus interactions

This paper uses 3D light sheet fluorescence microscopy to analyze fungal growth and immune responses in murine models of invasive pulmonary aspergillosis, revealing differences in fungal architecture and immune cell interactions across immunosuppressive regimens.