Cell BiologybioRxiv
Ataxia Telangiectasia patient-derived neuronal and brain organoid models reveal mitochondrial dysfunction and oxidative stress
H. C. Leeson, J. Aguado, C. Gomez-Inclan…·E. J. Wolvetang
This study uses patient-derived iPSCs and organoids to show mitochondrial dysfunction and oxidative stress in AT, which can be mitigated by ATM correction or antioxidants.