Alpha-synuclein oligomers displace monomeric alpha-synuclein from lipid membranes
G. Sneideriene, M. A. Czekalska, C. K. Xu, A. Jayaram, G. Krainer, W. E. Arter, Q. Peter, M. Castellana-Cruz, K. L. Saar, A. Levin, T. Mueller, S. Fiedler, S. R. A. Devenish, H. Fiegler, J. R. Kumita, T. Knowles
This study shows that alpha-synuclein oligomers bind more strongly to curved lipid membranes and displace monomeric alpha-synuclein, suggesting a new mechanism for Parkinson's disease toxicity.
bioRxiv · Mar 21, 2023Biophysics