Tryptophan wasting and disease activity as a systems phenomenon in inflammation - an analysis across 13 chronic inflammatory diseases.
D. M. Harris, S. Szymczak, S. Schuchardt, J. Labrenz, F. Tran, L. Welz, H. Grasshoff, H. Zirpel, M. Suembuel, M. Oumari, N. Engelbogen, R. Junker, C. Conrad, D. Thaci, N. Frey, , K. Aden
This study examines tryptophan wasting across 13 chronic inflammatory diseases, finding reduced serum tryptophan levels and increased kynurenine pathway activity linked to disease activity.
bioRxiv · Aug 25, 2023 · PreprintImmunology