C. Conrad

Population dynamics after pancreatitis dictates long-lasting epigenetic reprogramming and mediates tumor predisposition

This study shows that acute pancreatitis induces epigenetic changes in acinar cells, leading to long-term tumor predisposition through altered cell states and plasticity.

The DivisionCounter, a method for counting large ranges of cell divisions in vivo, reveals cell dynamics of leukemic cell killing via CAR-T therapy

The paper introduces DivisionCounter, a method to count large cell divisions in vivo, showing leukemia tumor division rates are independent of microenvironment and CAR-T treatment.

Loss of neutrophil Shp1 produces hemorrhagic and lethal acute lung injury

This study shows that loss of neutrophil Shp1 causes severe lung injury and death in mice, and that activating Shp1 can reduce inflammation and lung damage.

Humanized in vivo bone marrow models orchestrate multi-lineage human hematopoietic cell development

This study characterizes a humanized in vivo bone marrow model, hOss, showing its impact on human hematopoietic development and clonal interactions.

Tryptophan wasting and disease activity as a systems phenomenon in inflammation - an analysis across 13 chronic inflammatory diseases.

This study examines tryptophan wasting across 13 chronic inflammatory diseases, finding reduced serum tryptophan levels and increased kynurenine pathway activity linked to disease activity.

Detection of a geminate photoproduct of bovine cytochrome c oxidase by time-resolved serial femtosecond crystallography

The paper detects a geminate photoproduct of bovine cytochrome c oxidase using time-resolved serial femtosecond crystallography, revealing the ligand dissociation trajectory and protein dynamics.

Optimizing anesthesia and delivery approaches for dosing into lungs of mice

This study compares pulmonary dosing efficiency in mice under different anesthetic and delivery methods, finding that ketamine/xylazine anesthesia and oropharyngeal aspiration improve lung delivery compared to isoflurane and intranasal dosing.

DRAG in situ barcoding reveals an increased number of HSPCs contributing to myelopoiesis with age

This study uses an in situ lineage tracing method to show that aging increases the number of HSPCs contributing to myelopoiesis, not their individual output.

Transcriptionally defined morphological subtypes of pancreatic ductal adenocarcinoma

The paper identifies five transcriptional subtypes of PDAC cells with distinct morphological patterns and confirms their prognostic significance using bulk RNA-sequencing datasets.

Nuclear envelope disruption triggers hallmarks of aging in lung alveolar macrophages

This study shows that Lamin A/C protects lung alveolar macrophages from nuclear envelope rupture and aging-related DNA damage, linking NE disruption to genomic instability and senescence.

The molecular evolution of spermatogenesis across mammals

This study analyzes single-nucleus transcriptomes from testes across eleven mammalian species to uncover molecular evolution patterns in spermatogenesis.

Deep molecular characterization linked to drug response profiling of pancreatic ductal adenocarcinoma using patient-derived organoids.

This study uses patient-derived PDAC organoids to integrate genomic, transcriptomic, and drug response data, identifying novel biomarkers and resistance mechanisms for personalized treatment.

Intratumoural heterogeneity and immune modulation in lung adenocarcinoma of female smokers and never smokers

The paper examines intratumoural heterogeneity and immune modulation in lung adenocarcinoma, focusing on female smokers and never smokers, identifying distinct cellular subpopulations and immune interactions.

Validation of Functional Polymorphisms Affecting Maize Plant Height by Unoccupied Aerial Systems (UAS) allows Novel Temporal Phenotypes

The paper validates two maize PHT QTVs using UAS to show their dynamic effects across genetic backgrounds and growth stages, revealing overlooked phenotypic variability.

Single-cell analysis of patient-derived PDAC organoids reveals cell state heterogeneity and a conserved developmental hierarchy

The paper uses single-cell RNA sequencing to analyze PDAC organoids and identifies conserved cell states and a differentiation hierarchy linked to tumor subtypes.

Defining the RBPome of T helper cells to study higher order post-transcriptional gene regulation

The paper identifies the core RNA-binding protein (RBP)ome in human and mouse T helper cells, revealing new regulators of post-transcriptional gene regulation, including Celf1 as a Roquin-1-dependent coregulator of Icos.

Erythropoietin directly remodels the clonal composition of murine hematopoietic multipotent progenitor cells

This study shows EPO directly affects murine hematopoietic multipotent progenitor cells by altering their clonal composition and inducing erythroid gene expression.

Automated screening by 3D light-sheet microscopy with high spatial and temporal resolution reveals mitotic phenotypes

The paper presents a workflow using 3D light-sheet microscopy and automated image processing to screen mitotic phenotypes in 3D cell cultures with high throughput.

Induced aneuploidy disrupts MCF10A acini formation and CCND1 expression

This study shows that induced aneuploidy disrupts MCF10A acini formation and upregulates CCND1 expression through altered promoter-enhancer interactions.

Modeling glioblastoma invasion using human brain organoids and single-cell transcriptomics

This study uses human brain organoids and single-cell transcriptomics to model GBM invasion, identifying transcriptional changes and potential therapeutic targets.

Resolving Drug Effects In Patient-Derived Cancer Cells Links Organoid Responses To Genome Alterations

The paper compares drug responses in ovarian cancer organoids and monolayer cultures, finding differences in drug efficacy and genomic associations.