Author

K. Aden

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Cell Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Research Focus:host-pathogen & immune response· 2 Assay:metabolomics· 2 Research Focus:cell type annotation· 1 Research Focus:clustering· 1

Frequent Co-Authors

P. Rosenstiel· 4 shared S. Schreiber· 4 shared A. Franke· 2 shared D. M. Harris· 2 shared F. Tran· 2 shared L. Welz· 2 shared M. Oumari· 2 shared N. Frey· 2 shared

Activity by Year

2022-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersImmunology

P. Rosenstiel

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Hexokinase 2 expression in apical enterocytes correlates with inflammation severity in patients with inflammatory bowel disease

S. Weber-Stiehl, J. Taubenheim, L. Jaerke, C. Roecken, S. Schreiber, K. Aden, C. Kaleta, P. Rosenstiel, F. Sommer

The paper examines the relationship between HK2 expression and inflammation severity in IBD patients using bulk transcriptome data and confirms findings at the cellular and protein levels.

bioRxiv · Apr 4, 2024Immunology

Tryptophan wasting and disease activity as a systems phenomenon in inflammation - an analysis across 13 chronic inflammatory diseases.

D. M. Harris, S. Szymczak, S. Schuchardt, J. Labrenz, F. Tran, L. Welz, H. Grasshoff, H. Zirpel, M. Suembuel, M. Oumari, N. Engelbogen, R. Junker, C. Conrad, D. Thaci, N. Frey, , K. Aden

This study examines tryptophan wasting across 13 chronic inflammatory diseases, finding reduced serum tryptophan levels and increased kynurenine pathway activity linked to disease activity.

bioRxiv · Aug 25, 2023 · PreprintImmunology

Amino acid auxotrophies in human gut bacteria are linked to higher microbiome diversity and long-term stability

S. Starke, D. M. Harris, J. Zimmermann, S. Schuchardt, M. Oumari, D. Frank, C. Bang, P. Rosenstiel, S. Schreiber, N. Frey, A. Franke, K. Aden, S. Waschina

This study links amino acid auxotrophies in human gut bacteria to increased microbiome diversity and long-term stability through a combined metabolomic, metagenomic, and metabolic modeling approach.

bioRxiv · Mar 23, 2023Microbiology

Metabolic plasticity of serine metabolism is crucial for cGAS/STING-signalling and innate immune response to viral infections in the gut

B. Becker, F. Wottawa, M. Bakr, E. Koncina, L. Mayr, J. Kugler, G. Yang, S. J. Windross, L. Neises, N. Mishra, D. Harris, F. Tran, L. Welz, J. Schwaerzler, Z. Banki, , K. Aden

The paper identifies metabolic changes in serine metabolism linked to cGAS/STING-signalling and immune response in gut inflammation.

bioRxiv · May 17, 2022 · PreprintCell Biology