Author

H. J. Sharpe

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Organism:human· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1 Assay:structural biology· 1

Frequent Co-Authors

I. M. Hay· 2 shared J. E. Deane· 2 shared A. S. A. Mohammed· 1 shared C. M. Jeffries· 1 shared D. I. Svergun· 1 shared E. R. Caroe· 1 shared G. W. Fearnley· 1 shared M. Koehn· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersBiochemistry

I. M. Hay

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2 papers

Recent·Most cited

BiochemistrybioRxivJun 23, 2022

Determinants of receptor tyrosine phosphatase homophilic adhesion: structural comparison of PTPRK and PTPRM extracellular domains

I. M. Hay, M. Shamin, E. R. Caroe…·J. E. Deane

This study compares the structural features of PTPRK and PTPRM extracellular domains to identify determinants of homophilic adhesion, finding that shape complementarity and limited sequence differences drive specificity.

DOI 10.1016/j.jbc.2022.102750

structural biologyexperimental assay

𝕏 PostBluesky

BiochemistrybioRxivOct 16, 2019

The receptor PTPRU is a redox sensitive pseudophosphatase

I. M. Hay, G. W. Fearnley, P. Rios…·J. E. Deane

This paper shows that PTPRU is a pseudophosphatase with no catalytic activity, functioning instead by competing with active phosphatases for substrate binding.

DOI 10.1038/s41467-020-17076-w

humanproteomics

𝕏 PostBluesky