Cell BiologybioRxiv
Structural basis for autophagy inhibition by the human Rubicon-Rab7 complex
H. K. Bhargava, K. Tabata, J. K. Byck…·J. H. Hurley
This study determines the crystal structure of the Rubicon RH domain bound to Rab7-GTP, revealing its mechanism of autophagy inhibition and validating it as a therapeutic target.
DOI 10.1073/pnas.2008030117