Autophagy suppression in DNA damaged cells occurs through a newly identified p53-proteasome-LC3 axis
D. J. Lieu, M. K. Crowder, J. R. Kryza, B. Tamilselvam, P. J. Kaminski, I.-J. Kim, Y. Li, E. Jeong, M. Enkhbaatar, H. Chen, S. B. Son, H. Mok, K. A. Bradley, H. Phillips, S. R. Blanke
The paper identifies a p53-proteasome-LC3 axis that suppresses autophagy in DNA damaged cells, linking p53 stabilization to reduced LC3A/B levels.
bioRxiv · May 21, 2024 · PreprintCell Biology