Cell BiologybioRxiv
IL8 Drives an Elaborate Signal Transduction Process for CD38 to Produce NAADP from NAAD and NADP+ in Endolysosomes to Effect Cell Migration
T.-S. Nam, D.-R. Park, S.-Y. Rah…·U.-H. Kim
The paper reveals how IL8 triggers a signaling pathway that enables CD38 to produce NAADP in endolysosomes, driving calcium signaling and cell migration.
DOI 10.1096/fj.202001249r