Author

C. Brenner

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Pathology· 2 Cell Biology· 1 Immunology· 1 Microbiology· 1 Physiology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 5 Organism:mouse· 4 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Organism:human· 3 Assay:metabolomics· 3 Assay:proteomics· 3 Assay:bulk RNA-seq· 2

Frequent Co-Authors

M. S. Schmidt· 4 shared B. London· 2 shared J.-Y. Yoon· 2 shared K. Irani· 2 shared A. J. Covarrubias· 1 shared A. Kale· 1 shared A. M. Greiner· 1 shared A. Oliveira Pisco· 1 shared

Activity by Year

2019-2022 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersMicrobiology

M. S. Schmidt

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Metabolic rescue ameliorates mitochondrial encephalo-cardiomyopathy in murine and human iPSC models of Leigh syndrome

J.-Y. Yoon, N. Daneshgar, Y. Chu, B. Chen, M. Hefti, K. Irani, L.-S. Song, C. Brenner, E. D. Abel, B. London, D.-F. Dai

This study shows that metabolic rescue with nicotinamide riboside improves mitochondrial encephalo-cardiomyopathy in mouse and human iPSC models of Leigh syndrome.

bioRxiv · Jan 4, 2022Pathology

Coronavirus infection and PARP expression dysregulate the NAD Metabolome: an actionable component of innate immunity

C. D. Heer, D. J. Sanderson, L. S. Voth, Y. M. O. Alhammad, M. S. Schmidt, S. A. J. Trammell, S. Perlman, M. S. Cohen, A. R. Fehr, C. Brenner

This study shows that SARS-CoV-2 infection upregulates MARylating PARPs and NAD synthesis enzymes, and that enhancing NAD levels can reduce viral replication.

bioRxiv · Apr 17, 2020Microbiology

The NAD Metabolome is Functionally Depressed in Patients Undergoing Liver Transplantation for Alcohol-related Liver Disease

R. Parker, M. S. Schmidt, O. Cain, B. Gunson, C. Brenner

This study quantifies the NAD+ metabolome in human liver samples from patients with alcohol-related liver disease and finds reduced NAD+ and precursor levels associated with disease activity.

bioRxiv · Mar 28, 2020Pathology

IL8 Drives an Elaborate Signal Transduction Process for CD38 to Produce NAADP from NAAD and NADP+ in Endolysosomes to Effect Cell Migration

T.-S. Nam, D.-R. Park, S.-Y. Rah, T.-G. Woo, H. T. Chung, C. Brenner, U.-H. Kim

The paper reveals how IL8 triggers a signaling pathway that enables CD38 to produce NAADP in endolysosomes, driving calcium signaling and cell migration.

bioRxiv · Mar 24, 2020Cell Biology

Modulation of the Cardiac Sodium Channel Nav1.5 Peak and Late Currents by NAD+ Precursors

D. Matasic, J.-Y. Yoon, J. M. McLendon, H. Mehdi, M. S. Schmidt, A. M. Greiner, P. Quinones, G. M. Morgan, R. L. Boudreau, K. Irani, C. Brenner, B. London

This study investigates how NAD+ precursors NR and NAM affect NaV1.5 currents and cardiac electrophysiology, finding NR increases peak INa and reduces INa,L while NAM has mixed effects.

bioRxiv · Feb 20, 2020Physiology

Aging-related inflammation driven by cellular senescence enhances NAD consumption via activation of CD38+ macrophages

A. J. Covarrubias, A. Kale, R. Perrone, J. A. Lopez-Dominguez, A. Oliveira Pisco, H. G. Kasler, M. S. Schmidt, C. D. Wiley, S. S. Iyer, N. Basisty, Q. Wu, R. Kwok, I. Heckenbach, K.-O. Shin, Y.-M. Lee, , E. Verdin

This study identifies CD38+ macrophages as a driver of NAD decline during aging through inflammation linked to cellular senescence in metabolic tissues.

bioRxiv · Jul 31, 2019Immunology