Cell BiologybioRxivPreprint
Extracellular matrix stiffness regulates degradation of the Hippo kinase MST2 via SCFβTrCP
A. P. Z. P. Fiore, A. M. R. da Silva, H. V. Ribeiro…·A. Bruni-Cardoso
This study shows that ECM stiffness promotes MST2 degradation via SCFβTrCP ubiquitination, affecting YAP nuclear localization and mechanoregulated processes in breast epithelial cells.
DOI 10.1101/2021.01.31.429078