Halima Medjahed

Nef and Vpu protect infected cells from ADCP mediated by plasma from people with HIV-1

This study shows that HIV-1 infected cells with open Env conformations are vulnerable to ADCP mediated by PWH plasma, and that Nef and Vpu protect against this by preventing premature Env opening.

Conformational dynamics of the HIV-1 envelope glycoprotein from CRF01_AE is associated with susceptibility to antibody-dependent cellular cytotoxicity

This paper shows HIV-1CRF01_AE Env frequently adopts an open conformation (State 2A) that is susceptible to ADCC, unlike clade A/B Envs which require anti-cluster A antibodies to reach this state.

The asymmetric opening of HIV-1 Env by a potent CD4 mimetic enables anti-coreceptor binding site antibodies to mediate ADCC

This study shows that the CD4 mimetic CJF-III-288 enables anti-CoRBS antibodies to mediate ADCC by stabilizing an asymmetric open Env conformation.

The HIV-1 envelope cytoplasmic tail protects infected cells from ADCC by downregulating CD4

This study shows that the HIV-1 envelope cytoplasmic tail downregulates CD4, protecting infected cells from ADCC by preventing Env conformational changes that expose epitopes recognized by CD4i antibodies and plasma from PLWH.

CD4 downregulation precedes Env expression and protects HIV-1-infected cells from ADCC mediated by non-neutralizing antibodies

The paper shows CD4 downregulation precedes Env expression in HIV-1-infected cells, making them resistant to non-neutralizing antibody-mediated ADCC.

The combination of three CD4-induced antibodies targeting highly conserved Env regions with a small CD4-mimetic achieves potent ADCC activity

This paper combines three CD4-induced antibodies with a CD4-mimetic to achieve potent ADCC activity against HIV-1-infected cells.

Structure-function Analyses Reveal Key Molecular Determinants of HIV-1 CRF01_AE Resistance to the Entry Inhibitor Temsavir

This study identifies multiple molecular determinants of HIV-1 CRF01_AE resistance to temsavir, showing that resistance involves crosstalk between His375 and inner domain layers.

Decline of humoral responses against SARS-CoV-2 Spike in convalescent individuals

The paper tracks humoral responses against SARS-CoV-2 Spike in convalescent individuals over time, finding declines in IgG and IgM and neutralization capacity.