Jérémie Prévost

This paper shows HIV-1CRF01_AE Env frequently adopts an open conformation (State 2A) that is susceptible to ADCC, unlike clade A/B Envs which require anti-cluster A antibodies to reach this state.

This study shows that the HIV-1 envelope cytoplasmic tail downregulates CD4, protecting infected cells from ADCC by preventing Env conformational changes that expose epitopes recognized by CD4i antibodies and plasma from PLWH.

The paper shows CD4 downregulation precedes Env expression in HIV-1-infected cells, making them resistant to non-neutralizing antibody-mediated ADCC.

This paper combines three CD4-induced antibodies with a CD4-mimetic to achieve potent ADCC activity against HIV-1-infected cells.

This study identifies multiple molecular determinants of HIV-1 CRF01_AE resistance to temsavir, showing that resistance involves crosstalk between His375 and inner domain layers.

The paper tracks humoral responses against SARS-CoV-2 Spike in convalescent individuals over time, finding declines in IgG and IgM and neutralization capacity.