Han L. Tan

Magel2 deficiency drives microglial synaptic engulfment and alters neuron-microglia interactions in Prader-Willi syndrome

This study shows that Magel2 deficiency in a mouse model of Prader-Willi syndrome causes microglial structural changes and increased synaptic engulfment, altering neuron-microglia interactions and hypothalamic circuit function.

Rescuing Neurodevelopmental Deficits in AMPA Receptor Gain-of-Function Mutant

This study identifies a gain-of-function mutation in GRIA1 causing neurodevelopmental deficits and shows that an antisense oligonucleotide can prevent pathology and behavioral issues.

Leptin Activated Hypothalamic BNC2 Neurons Acutely Suppress Food Intake

The paper identifies BNC2 neurons in the hypothalamus that acutely suppress food intake by inhibiting AGRP neurons and are regulated by leptin, sensory cues, and nutritional status.

Visualizing synaptic plasticity in vivo by large-scale imaging of endogenous AMPA receptors

The paper develops tools to track synaptic plasticity in vivo by imaging endogenous AMPA receptors and generates a detailed spatiotemporal map of synaptic changes during behavior.