Richard L. Huganir

This study optimizes IVF procedures in common marmosets by identifying factors like progesterone levels and stimulation duration that improve embryo development and implantation rates.

The paper optimizes sperm processing and cryopreservation methods in common marmosets to improve motility and reduce DNA fragmentation for IVF applications.

This study shows that neuronal hyperactivity selectively increases tau phosphorylation at S202/T205 in excitatory hippocampal neurons, which reduces GluA2 surface expression and may contribute to Alzheimer's disease pathology.

The paper identifies sex and experience-dependent regulation of synaptic protein turnover using SILAM in the hippocampus, finding sex-specific changes in ASD risk genes and experience-induced stabilization of PSD proteins.

The paper develops sensitive FRET biosensors to visualize CaMKII activity dynamics in living cells and demonstrates their use in cultured and primary cells, including neurons and cardiomyocytes.

This study identifies a gain-of-function mutation in GRIA1 causing neurodevelopmental deficits and shows that an antisense oligonucleotide can prevent pathology and behavioral issues.

This study shows that Syngap1 absence or haploinsufficiency does not affect murine neocortical progenitor properties or output, suggesting species-specific or methodological differences in SYNGAP1's role in neurogenesis.

The paper identifies 70 extracellular proteins interacting with AMPARs during synaptic plasticity, showing OBCAM and NTM regulate AMPAR mobility.

This paper demonstrates that CRISPR-mediated transcriptional activation can upregulate SYNGAP1 in a mouse model of SRID and human neurons, rescuing deficits without targeting mutations.

The paper introduces SynTrack, a novel algorithm for tracking synaptic dynamics in vivo, achieving high accuracy and scalability in longitudinal synapse tracking.

This study uses single-cell long-read sequencing to profile experience-induced gene and isoform expression in mouse hippocampal cells, identifying 1,266 experience-variable isoforms.

This study investigates the structural features of GluA4 AMPA receptors, revealing their unique architecture and conformational plasticity that influence ion channel function and disease relevance.

This study shows that SYNGAP1's structural role, not its enzymatic GAP activity, is critical for seizure susceptibility in heterozygous KO mice, while its GAP activity affects intrinsic excitability.

The paper develops a convolutional neural network to detect and segment fluorescently labeled synapses in vivo, enabling large-scale analysis of synapses in living mice.

The paper determines the structure of the TARP subunit γ2 using cryo-EM and identifies structural motifs that differentiate TARPs from claudins and explain subfamily variations.

This study shows that calcium-permeable AMPA receptors (CP-AMPARs) in PV interneurons reduce their feature selectivity, and removing them increases selectivity in visual cortex and hippocampus.

This study shows that deletion of the proton-activated chloride channel in neurons leads to endosomal hyper-acidification, impairing AMPA receptor endocytosis and long-term depression.

This study reveals how negative allosteric modulators inhibit AMPA receptors by disrupting glutamate binding and outcompeting positive modulators, offering insights for therapeutic design.

This study shows WWC2 regulates GABAAR trafficking at inhibitory synapses, distinct from its homolog KIBRA's role at excitatory synapses.

This study identifies experience-induced changes in the hippocampal PSD proteome and phosphoproteome in mice following inhibitory avoidance training or immediate shock.

This study generates zebrafish models of SYNGAP1 disorder and shows that syngap1ab mutants exhibit context-dependent hyperactivity linked to altered arousal states.

This paper generates two knock-in mouse models with human SYNGAP1 mutations causing intellectual disability, showing reduced protein levels and recapitulating key disease features.

This study shows SynGAP regulates synaptic plasticity and cognition through phase separation, not its catalytic activity.

This study identifies Btbd11 as an inhibitory interneuron-specific protein that supports glutamatergic synapse structure and function, with implications for neural circuitry and behavior.

The paper develops a deep learning image restoration method to enhance in vivo synaptic imaging resolution using ex vivo super-resolution techniques, enabling tracking of synaptic plasticity in living mice.

This study engineers novel adhesion molecules that drive synapse formation in cultured neurons by combining domains from bacterial proteins and synaptic cell-adhesion molecules.

This paper introduces ST-Cal-Light, a method to tag active neurons by converting somatic calcium signals into gene expression, enabling precise functional circuit analysis.

This study identifies the miR-124-AMPAR pathway as a common mediator linking polygenic risks to shared behavioral changes in schizophrenia and bipolar disorder.

The paper develops DELTA, a method to measure brain-wide synaptic protein turnover at single-synapse resolution, revealing localized plasticity in hippocampal CA1 during learning.

This paper introduces SLED, a splicing-based method to control gene expression in specific cell types, demonstrating its utility in targeting neurons, photoreceptors, and cancer cells.