Hanh T. Nguyen

This study investigates how truncations of the HIV-1 Env cytoplasmic tail affect Env cleavage, incorporation into virions, and antibody neutralization.

The paper investigates how many HIV-1 Env protomers need to be modified to stabilize or destabilize the pretriggered conformation, finding that stabilization requires fewer modified protomers than destabilization.

The paper shows that expressing broadly or poorly neutralizing antibodies or CD4 in HIV-1-producing cells reduces viral infectivity by disrupting Env processing and incorporation into virions.

The paper describes the engineering of HIV-1 Env variants enriched in a pretriggered conformation, which are more stable and crosslinkable, aiding in structural and immunogenic studies.

This study investigates the conformational plasticity of the uncleaved HIV-1 Env trimer and its implications for antibody recognition and Env cleavage.